The isoprenoid biosynthesis pathway and regulation of osteoblast differentiation
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چکیده
Approved: ______________________________________________ Thesis Supervisor ______________________________________________ Title and Department ______________________________________________ Date THE ISOPRENOID BIOSYNTHESIS PATHWAY AND REGULATION OF OSTEOBLAST DIFFERENTIATION by Megan Moore Weivoda A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Pharmacology in the Graduate College of The University of Iowa
منابع مشابه
Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation.
Statins, drugs commonly used to lower serum cholesterol, have been shown to stimulate osteoblast differentiation and bone formation. Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). The effects of s...
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تاریخ انتشار 2016